Voprosy meditsinskoi khimii (ISSN 0042-8809)

Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing

   


1. Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. Biological Faculty, Moscow State University
PubMed Id: 12698556
Year: 2002 vol: 48  issue:6  pages: 570-576
Abstract: Polymer dressings with encapsulated thrombin or synthetic peptides which can mimic thrombin action are employed for wound healing. Paper describes the method for preparation of these hydrogel composites of PVCL-CaAlg [poly(N-vinyl caprolactam-calcium alginate). The effect of encapsulated thrombin/peptides on tissue repair process have beet investigatat in vivo experiments using a mouse model of wound healing. The developed dressings accelerated wound healing: thascan be used as a basis for creation of novel formulations with controlled drug release for wound therapy.
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Reference: Markvicheva E.A., Kuptsova S.V., Rumsh L.D., Dugina T.N., Lange M.A., Chistov I.V., Strukova S.M., Zubov V.P., Polymer dressings with encapsulated thrombin orpeptides : preparation and use for wound healing , Voprosy meditsinskoi khimii, 2002, vol: 48(6), 570-576.
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