Voprosy meditsinskoi khimii (ISSN 0042-8809)

Comparative analysis differentiating andapoptogenic effects of cytidine, thymidine and guanosine on human erythroleukaemic k562cells

   


1. Petrozavodsk State University
PubMed Id: 12698558
Year: 2002 vol: 48  issue:6  pages: 586-593
Abstract: The antiproliferative, differentiating and apoptogenic effects of purinic (cytidine andthymidine) and pyrimidinic (guanosine) nucleosides on K562 cells were investigated.Induction of erythroid differentiation (haemoglobin synthesis) in cancer cells wasobserved after 2 and 4 days incubation with 2 mM thymidine and 1 mM guanosine. Increase ofhaemoglobin synthesis in K 562 cells incubated with 2 mM cytidine was detected at 4 day.Analysis of the DNA-degrading effect (induction of apoptosis) of the reagents used on K562 cells by fluorescent dyes and modulation activity of caspase 9 and also caspases3,7,10 is induced with thymidine and guanosine but not with cytidine.
Download PDF:
Reference: Volkova T.O., Malysheva I. E., Nemova N.N., Comparative analysis differentiating andapoptogenic effects of cytidine, thymidine and guanosine on human erythroleukaemic k562cells, Voprosy meditsinskoi khimii, 2002, vol: 48(6), 586-593.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)