The intermolecular interactions of dipeptide derivatives of triterpenoids and natural quinones with a-tocopherol

   


1. Tyumen State Medical Academy
2. Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences
3. Institute of Biochemical Physics, Russian Academy of Sciences
Type: Experimental/clinical study
PubMed Id: 14569879
Year: 2003 vol: 49  issue:1  pages: 96-104
Abstract: In modeling system of the initiated oxidation of methyl oleate the antioxidation activity of a series of dipeptide derivatives of betulonic and glycyrrhetic acids, natural quinones (ubiquinone, philloquinone and menadione) and the kinetic effects of their combined action with a-tocopherol were studied. The same extreme character of the dependence of inhibitory action on the concentration of all investigated substances was found. Combined addition of triterpenoids or quinones together with a-tocopherol attenuated their effect. The mechanism of intermolecular interactions of tocopherol with quinones and triterpenoids is offered. The biological importance of these effects is discussed.
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Reference: Storozhok N.M., Tsymbal I.N., Petrenko N.I., Shults E.E., Khrapova N.G., Tolstikov G.A., Burlakova E.B., The intermolecular interactions of dipeptide derivatives of triterpenoids and natural quinones with a-tocopherol, Biomeditsinskaya khimiya, 2003, vol: 49(1), 96-104.
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