1. 29 Municipal Hospital of Moscow Public Health Department 2. Neurology Research Institute, RAMS, Moscow 3. 29 Municipal Hospital of Moscow Public Health Department, Orekhovich Research Institute оf Biomedical Chemistry RAMS
Abstract: Serum levels of interferon-g (IFg), tumor necrosis factor alpha (TNFa) and autoantibodies (a-AT) to these cytokines were investigated in patients with Parkinson's disease (PD). The increased levels of TNFa (50%) and IFg (35%) were found in PD patients. There was close correlation between the serum level of TNFa and the manifestation of neurological symptoms (r = 0.434; p <0.05), and between levels of IFg and the duration of this disease (r = 0.4511, p <0.05) and patients age as well (r = 0.4358; p <0.05). There was increased level of a-AT to TNFa in PD patients versus helthy controls (130.3±11.92 and 105.3±4.62, respectively, p <0.05). The combined increase of levels of a-AT to TNFa and IFg (r = 0.91, p <0.01), close reverse correlation between duration of PD and levels of a-AT to TNFa and IFg (r=0.4644 and r = 0.606, respectively, p<0.01) were also recognised. The data obtained suggest the involvement of TNFa and IFg into the pathological process during PD, which requires further investigation in this direction.
Reference: Gribova I.E., Gnedenko B.B., Poleshchuk V.V., Morozov S.G., Content of interferon-gamma, alpha tumor necrosis factor and autoantibodies to them in blood serum during parkinson's disease, Biomeditsinskaya khimiya, 2003, vol:
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