Antioxidants in malignant human and experimental tumors


1. Institute of Urology, Ministry of Public Health Care of Russian Federation
2. Orekhovich Institute of Biomedical Chemistry RAMS
Type: Review
PubMed Id: 14564734
Year: 2003 vol: 49  issue:3  pages: 250-262
Abstract: This review is devoted to the role of low molecular weight antioxidants and antioxidant enzymes in cancerogenesis. The data are analyzed on accumulation of lipid-soluble and water-soluble antioxidants in a number of malignant human and experimental tumors especially in the renal cell carcinoma tissues. A possibility is discussed concerning the pro- and anticancerogenic effects of the abundant tumor content of antioxidants. Implication of antioxidants in tumor resistance to chemotheraputic drugs and ionazing radiation is discussed as well.
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Reference: Nikiforova N.V., Berman A.E., Antioxidants in malignant human and experimental tumors, Biomeditsinskaya khimiya, 2003, vol: 49(3), 250-262.