1. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine
Type: Review
PubMed Id: 14562680
Year: 2003 vol: 49  issue:4  pages: 333-359
Abstract: At least two types of cell death are known: physiological (apoptosis) and pathological (necrosis). Dysregulation of apoptosis plays an important role in the pathogenesis of many pathological conditions. Their analysis gives a key for the development of novel therapeutic approaches. In this review the recent advances and perspectives for clinical use of apoptosis-modulating monoclonal antibodies, low-molecular-weight proteins, peptides, small non-peptide molecules and drugs targeting apoptosis-associated genes are summarized. The rationale for clinical application of apoptomodulators with the aim of increasing efficacy of existing standard therapies are also discussed.
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Reference: Filchenkov A.N., Apoptomodulators, Biomeditsinskaya khimiya, 2003, vol: 49(4), 333-359.