Myelin oligodendrogliocyte glycoprotein the structure, functions, role in pathogenesis of demyelinating diseases

   


1. Serbsky National Research Centre For Social and Forensic Psychiatry
Type: Review
PubMed Id: 16119093
Year: 2003 vol: 49  issue:5  pages: 411-423
Abstract: Myelin oligodendrocyte glycoprotein (MOG) is a myelin-specific protein of the central nervous system (CNS). It is a member of the immunoglobulin superfamily. The contents of this protein in oligodendrogliocyte membrane is very low (approximately 0.1% total proteins). functions of MOG are still unknown. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review.
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Reference: Chekhonin V.P., Semenova A.V., Gurina O.I., Dmitrieva T.B., Myelin oligodendrogliocyte glycoprotein the structure, functions, role in pathogenesis of demyelinating diseases, Biomeditsinskaya khimiya, 2003, vol: 49(5), 411-423.
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