Effects of metformin on endocrine parameters and reproductive system in women with polycystic ovary syndrome

   


1. Department Endocrinology and Diabetology of the RMAPE
2. Research Center for Obstetrics, Gynecology and Perinatology of the RAMS
Type: Experimental/clinical study
PubMed Id: 16119083
Year: 2003 vol: 49  issue:6  pages: 548-553
Abstract: The effect of metformin has been studied among 42 patients of reproductive age with polycystic ovary syndrome. Therapy for 6-months was associated with regular menstrual cycle in 54,3% women, (ovulation was observed in 28,6%). After therapy 19,1% patients became pregnant. Serum levels LH fell from 16.3±1.45 to 8.9±0.82 IU/l, T from 3.3±0.17 to 2.0±0.17 nmol/l, (p<0.01). We noted increase of GH from 2,7±0,98 to 9,0±1,91nmol/l and SHBG from 36,4± 2,6 to 58,2±4,11 nmol/l, (p<0.01). After therapy we observed decrease of insulin responses during oral glucose tolerance test, (p<0.05).
Download PDF:
Reference: Valueva L.G., Chernukha G.E., Ametov A.S., Effects of metformin on endocrine parameters and reproductive system in women with polycystic ovary syndrome, Biomeditsinskaya khimiya, 2003, vol: 49(6), 548-553.
Bibliography
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 2011(Vol:57)
 2010(Vol:56)
 2009(Vol:55)
 2008(Vol:54)
 2007(Vol:53)
 2006(Vol:52)
 2005(Vol:51)
 2004(Vol:50)
 2003(Vol:49)