Flotation mass-spectra and negative surface potential of low density lipoprotein particles of hyperlipidemic patients after emergency abolishing for lavostatin treatment

   


1. Russian Cardiology Research Center
2. Orekhovich Institute of biomedical chemistry, Russian Academy of Medical Sciences
Type: Experimental/clinical study
PubMed Id: 16119085
Year: 2003 vol: 49  issue:6  pages: 566-575
Abstract: The lipid status of lovastatin-treated hyperlipidemic patients with documented atherosclerosis of coronary arteries and carotid artery atheroma without signs of calcinosis significantly changed 4 weeks after termination of lovastatin therapy. LDL flotation mass-spectra were shown to be a sensitive indicator of variations of the lipid status. All LDL mass-spectra can be subdivided into four subfractions (from 12 to 32 S at solvent density of 1.170 g/ml and a step of 5 S). Taking into consideration previous data on total electronegative charge of LDL subfractions flotation mass-spectra indicate that lovastatin caused reduction of total negative surface charge of LDL by 1.8-fold mainly due to reduction of (17-22) and (22-27) S. However, in patients with high level of triglycerols reduction of LDL electronegative charge was due to decrease of cholesterol in (17-22) S subfraction. The latter consists of the smallest particles of the highest density. Combined analysis of similarity in lipid parameters and flotation mass-spectra of LDL allows recognizing rather homogenous groups of patients demonstrating similar responsiveness to lovastatin therapy.
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Reference: Morozkin A.D., Soumarokov A.B., Medvedeva N.V., Lyakishev A.A., Flotation mass-spectra and negative surface potential of low density lipoprotein particles of hyperlipidemic patients after emergency abolishing for lavostatin treatment, Biomeditsinskaya khimiya, 2003, vol: 49(6), 566-575.
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