Determination of functional activity and concentration of C1 inhibitor and autoantibodies to it as the tool of differential diagnostics of angioedema

   


1. G.N.Gabrichevsky Moscow Scientific Research institute of Epidemiology and microbiology
Type: Experimental/clinical study
PubMed Id: 15108631
Year: 2004 vol: 50  issue:1  pages: 86-91
Abstract: Aetiology of angioedema (and therefore the scheme of its treatment) can be different. Angioedema may be subdivided into on four categories: hereditary angioedema (НАО), acquired, allergies and vasculitis. To establish the reason of the hereditary and acquired form of angioedema analyses of functional activity of complement components, quantities and activity of С1 inhibitor, presence (or absence) autoantibodies to С1 inhibitor allow. Sorption of the puried enzymes of activated subcomponent C1s or plasmin on micropanels allows to connect specifically in cells of plate С1 inhibitor from serum and with the help conjugate of antibodies against С1 inhibitor with a horse-radish peroxidase to determine quantity of connected functionally active С1 inhibitor. Addition of this test-system ELISE system for determination of quantitative contents of С1 inhibitor in serum, and also systems for definition IgG, IgA and IgM autoantibodies against С1 inhibitor finishes creation of a necessary set of methods of differential diagnostics.
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Reference: Anndina S.S., Kozlov L.V., Dyakov V.L., Determination of functional activity and concentration of C1 inhibitor and autoantibodies to it as the tool of differential diagnostics of angioedema, Biomeditsinskaya khimiya, 2004, vol: 50(1), 86-91.
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