Abstract: The effect of acute morphine intoxication (10, 20 and 40 mg/kg body weight) on the functioning of glycolysis in the rat liver was studied. The most pronounced effect was noted at the dose of 10 mg/kg. it included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased. The elevated morphine dose did not change glycolytic enzyme activities, decreasing glucose and glucose-6-phosphate contents.
Reference: Lelevich S.V., dose-dependent effects of morphine hydrochloride on the functioning of glycolysis in the rat liver, Biomeditsinskaya khimiya, 2004, vol:
1. Лелевич В.В., Селевич М.К., Патент Л.Ф. и др. (1999) Вопросы мед. химии, № 5, 357- 367. Scholar google search