dose-dependent effects of morphine hydrochloride on the functioning of glycolysis in the rat liver

   


1. Grodno State Medical University
Type: Experimental/clinical study
PubMed Id: 15354538
Year: 2004 vol: 50  issue:3  pages: 273-276
Abstract: The effect of acute morphine intoxication (10, 20 and 40 mg/kg body weight) on the functioning of glycolysis in the rat liver was studied. The most pronounced effect was noted at the dose of 10 mg/kg. it included activation of key glycolytic enzymes: hexokinase, glucokinase and phosphofructokinase and increase blood and liver tissue glucose being increased. The elevated morphine dose did not change glycolytic enzyme activities, decreasing glucose and glucose-6-phosphate contents.
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Reference: Lelevich S.V., dose-dependent effects of morphine hydrochloride on the functioning of glycolysis in the rat liver, Biomeditsinskaya khimiya, 2004, vol: 50(3), 273-276.
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