The influence of peroxide radicals and nitric oxide on DNA synthesis in tumor cells

   


1. Institute of Oncology, Tomsk Research Center, Siberian Branch of Russian Academy of Medical Sciences
Type: Experimental/clinical study
PubMed Id: 15707272
Year: 2004 vol: 50  issue:6  pages: 576-582
Abstract: The influence of peroxide radicals and nitric oxide (NO) on DNA synthesis in mouse Ehrlich's carcinoma cells was studied. Peroxyl radicals were generated from 2,2'-azo-bis(2-amidinopropane) (ABAP) and tert-buthyl hydroperoxide (t-BHP); NO was formed from sodium nitroprusside, sodium nitrite and L-arginine. The toxic effect of peroxide radicals and NO-generating compounds depended on their concentration in incubation medium. Combinations of NO donors with either ABAP or t-BHP in subtoxic concentrations did not result in marked decrease of tumor cell proliferation. The addition of non-toxic concentrations of NO generators failed or impaired the toxic effect of free radical agents. This protective action of NO may be associated with its antioxidant properties and may defend cancer cells from free-radical damage.
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Reference: Kondakova I.V., Zagrebelnaya G.V., The influence of peroxide radicals and nitric oxide on DNA synthesis in tumor cells, Biomeditsinskaya khimiya, 2004, vol: 50(6), 576-582.
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