Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics

   


1. Ulyanovsk state university
2. N.M.Emanuel Institute of Biochemical Physics
Type: Experimental/clinical study
PubMed Id: 15707275
Year: 2004 vol: 50  issue:6  pages: 600-604
Abstract: Administration of toxic doses of means specific tuberculostatics chemotherapy to rats caused development of medicinal damages of liver, kidneys, and pancreas. Use of 2-ethyl-6-methyl-hydroxypyridine succinate (SEMOP) and S-adenosyl-L-methionine reduced manifestations of pathological effects of tuberculostatics an organism of laboratory animals. There was clear dose-dependence of SEMOP effects. The highest cytoprotective effect was observed at the SEMOP dose of 50 mg/kg. Antioxidant properties of SEMOP determined it membrane protective effects.
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Reference: Katikova O.J., Rusov V.I., Smirnov L.D., Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinat of the gepatotoxyc, caused at rats introduction тuberculostatics, Biomeditsinskaya khimiya, 2004, vol: 50(6), 600-604.
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