An approach for selection of substances with specified metabolic properties

   


1. Chelyabinsk state medical academy
2. Chelyabinsk state university
Type: Experimental/clinical study
UDK: 541.69:541.572+615.781.6     
Year: 2004 vol: 50  application: 1  pages: 77-84
Abstract: An approach allowing to perform the preliminary selection of substances with specified metabolic properties is offered. The approach includes the classification of substances using 3D-QSAR algorithm BiS. It allows to fulfil the selection of substances being and not being P450 isoforms substrates depending on requirements. The same selection of substances can be required for the search of the drug candidates with specified metabolic properties in addition to the main pharmacological effect
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Reference: Pogrebnoy A.A., Ryabinin V.E., Potemkin V.A., Bartashevich E.V., Grishina M.A., An approach for selection of substances with specified metabolic properties, Biomeditsinskaya khimiya, 2004, vol: 50(application 1), 77-84.
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