1. Kharkov National University 2. Institute of Children and Adolescent Health Protection, Ukrainian Academy of Medical Sciences 3. V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences 4. Zaporozhye State Medical University
Abstract: The antioxidant action of the extract from Aronia melanocarpa leaves on the brain was investigated. The intraperitoneal injection of extract in the dose of 0.2 g/kg prevented manifestations of oxidative stress in the brain induced by immobilization of rats. In vitro experiments revealed that the extract decreased intensity of ascorbate - and Н2О2 -induced lipid and protein peroxidation in the brain homogenates. The most effect of the extract on ascorbate - induced lipid peroxidation was found in the postmitochondrial fraction of brain homogenate.
Reference: Suvorova I.N., Davydov V.V., Prozorovskiy V.N., Shvets V.N., Peculiarity of extract from aronia melanocarpa leaves antioxidant action for the brain, Biomeditsinskaya khimiya, 2005, vol: