Effects of small molecule hesperadin on breast and prostate cancer cell lines

   


1. Russian State Medical University, Fox Chase Cancer Center
2. Russian State Medical University
3. Fox Chase Cancer Center
Type: Experimental/clinical study
PubMed Id: 15945350
Year: 2005 vol: 51  issue:2  pages: 170-176
Abstract: Aurora B, Which is important for cell division control, is highly expressed in large number of cancer cell lines. Hesperadin, a prototype of a pharmacological agent, is a small molecule inhibitor of catalytic activity of Aurora B. In present work we investigate effect of Hesperadin on breast – MCF7 and prostate adenocarcioma – PC3, cancer cell lines. After Hesperadin treatment we observe stop of cell proliferation due to appearance of multiple mitotic defects caused by Aurora B. Activity reduction and elimination of checkpoint proteins – such as hBUBR1 and CENP-E – fron kinotochores of mitotic chromosomes/
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Reference: Ladygina N.G., Lacis R.V., Yen T., Effects of small molecule hesperadin on breast and prostate cancer cell lines, Biomeditsinskaya khimiya, 2005, vol: 51(2), 170-176.
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