Study of antiradicalactivity of new compounds by chemiluminescence


1. Volgograd State Medical Academy
2. Research Institute of Physics and Organic Chemistry
Type: Experimental/clinical study
PubMed Id: 16104391
Year: 2005 vol: 51  issue:3  pages: 287-294
Abstract: Antioxidative and antiradical properties of a new antioxidant cerebroprotective drug, enoxifol (benzimidasole derivative), were compared with mexidol by means of three chemiluminescent techniques: luminol autooxidation system, Fe2+-induced lipid chemiluminescence and lucigenin-induced chemiluminescence with superoxide generation by xanthine-xanthine oxidase system. Enoxifol exhibited higher antiradical than mexidol. This was shown by suppression of luminol radicals and superoxide anion-radical generation. Antioxidant properties of enoxifol were also demonstrated by decreasing of Fe2+-induced lipid chemiluminescence. The recognized properties of enoxifol influencingchemiluminescent processes confirm the results, obtained earlier by means of indirect methods of free radical processes study in vitro and in vivo (decrease of LPO products, activation of antioxidant enzymes), also can underline its pharmacological effects.
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Reference: Kosolapov V.A., Spasov A.A., Anisimova V.A., Study of antiradicalactivity of new compounds by chemiluminescence, Biomeditsinskaya khimiya, 2005, vol: 51(3), 287-294.