Abstract: There is evidence that cells respond not only to biologically active substances, but also to external mechanical effects. This is especially important for cellular elements of vascular walls and blood. Mechanical treatment cause so-called stretch-deformation of plasma membranes and forces generated by shift of plasma layers induce shear stress. Good experimental evidence exists that mechanical effects influence functional activity of vascular wall and blood cells.
Reference: Glushkov V.S., Storozhok S.A., Panchenko L.F., Silina E.G., Role of membrane deformations in regulation of functions of cells, Biomeditsinskaya khimiya, 2005, vol: