The effect of asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal

   


1. M. Ulugbek National University of Uzbekistan
Type: Experimental/clinical study
UDK:       PubMed Id: 16342667
Year: 2005 vol: 51  issue:5  pages: 513-518
Abstract: Administration of a cobra venom to rats resulted in decrease of heart and liver mitochondrial cardiolipins (1.88 and 1.29 times), phosphatidylethanolamines (1.56 and 1.42 times) and phosphatidic acid (1.14 and 1.29 times), whereas the content of phosphadtidylcholins increased by 1.42 and 1.51-fold, respectively. The content of phosphadtidylinositol increased by 3.09 times in liver mitochondria and decreased by 1.28 times in heart mitochondrial phosphadtidylserine content impaired after the venom administration but even exceeded it. Benzonal also minimized changes in mitochondrial phospholipid induced by the cobra venom, and also reduced liver and heart phosphatidic acid content by 1.36 and 1.7 times
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Reference: Shirinova I.A., Nurdinov Sh.Sh., Klemesheva L.S., Almatov K.T., The effect of asian cobra venom on the content of rat heart and liver mitochondrial phospholipids and the protective effect of benzonal, Biomeditsinskaya khimiya, 2005, vol: 51(5), 513-518.
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