Kinetics and actions mechanism of vitamin D3 in the process of lipid and blood plasma oxidation in model system

   


1. SGI HPE Tyumen State Medical Academy
Type: Experimental/clinical study
UDK:       PubMed Id: 16521829
Year: 2005 vol: 51  issue:6  pages: 662-672
Abstract: Kinetics and mechanism of vitamin D3 action were investigated in the process of initiated oxidation of various modeling systems in comparison with activity of various antioxidants such as: α-tocopherol, dibunol, α-tocopheryl quinone Q10, philloquinone and β-carotene. Vitamin D3 addition increased initial and maximal rates of oxygen consumption. The length of circuits, value of a kinetic parameter k2/√k6, describing oxidability of system as a whole was also increased. Cholecalciferol concentrations exceeding 7,5×10-6 M inhibited these processes. Increase of conjugated dienes was proportional to vitamin D3 concentration. Vitamin D3 did not influence kinetics of accumulation of TBA-reactive products. These results may be explained by high lability of cholecalciferol, which may represent an additional source of free radicals.
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Reference: Storozhok N.M., Daryuhina E.N., Tsvetkova E.Yu., Zhymbal I.N., Kinetics and actions mechanism of vitamin D3 in the process of lipid and blood plasma oxidation in model system, Biomeditsinskaya khimiya, 2005, vol: 51(6), 662-672.
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