Abstract: Parameters of hepatic free radical oxidation and catalytic properties of NADP-isocitrate dehydrogenase (EC 184.108.40.206; NADP-IDH) have been investigated in normal rats and under conditions of toxic hepatitis. Development of hepatitis was accompanied by the increase of conjugated dienes, malondialdehyde and some chemiluminescence parameters. Toxic hepatitis was also accompanied by the increase of liver NADP-IDH. Homogenous preparations of liver NADP-IDH from normal and toxic rats exhibited different sensitivity to effectors studied (Fe2+, Ca2+, H2O2, reduced glutatione).
Reference: Andreescheva E.M., Popova T.N., Artyukhov V.G., Rakhmanova T.I., Matasova L.U., The intensity of freeradical oxidation and catalyticproperties of rat liver NADP-isocitratedehydrogenasе in the norm and toxic hepatitis, Biomeditsinskaya khimiya, 2006, vol:
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