Correlation between succinate-dependent Cа2+ accumulation and transamination in heart and liver mitochondria of experimental animals

   


1. Institute of Theoretical and Experimental Biophysics, RAS
Type: Experimental/clinical study
UDK: 577.352.4      PubMed Id: 16898587
Year: 2006 vol: 52  issue:3  pages: 287-297
Abstract: Glutamate (GLU) and α-ketoglutarate (KGL), the substrates involved in transamination, have reciprocal effects on succinate-dependent respiration, NADH reduction, as well as on the accumulation and stable retention of Ca2+ in heart and liver mitochondria and homogenates from experimental animals. The succinate-dependent Ca2+ accumulation was shown to be highly sensitive to changes of the concentration ratios of GLU and KGL within the range 1:10 mM. GLU activated this process by transamination of oxalacetate (OAA) to aspartate. The predomination of KGL blocked the activating effect of GLU. The predomination of GLU eliminated the block produced by KGL or phosphoenolpyruvate (sources of OAA and GTP) but did not eliminate the Ca2+ accumulation-suppressing effect of aminoacetate, inhibitor of transaminases.
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Reference: Saakyan I.R., Saakyan G.G., Correlation between succinate-dependent Cа2+ accumulation and transamination in heart and liver mitochondria of experimental animals, Biomeditsinskaya khimiya, 2006, vol: 52(3), 287-297.
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