Abstract: Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+ATP-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.
Reference: Kulinsky V.I., Gavrilina T.V., Minakina L.N., Kovtun V.Yu., Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice, Biomeditsinskaya khimiya, 2006, vol:
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