Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice

   


1. Department of Biochemistry, Irkutsk State Medical University
2. Department of Pharmacology, Irkutsk State Medical University
3. SPC Pharmprotection
Type: Experimental/clinical study
UDK: 577.17:615.21:616.831-005.4      PubMed Id: 16898589
Year: 2006 vol: 52  issue:3  pages: 309-316
Abstract: Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+ATP-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.
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Reference: Kulinsky V.I., Gavrilina T.V., Minakina L.N., Kovtun V.Yu., Biochemico-pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice, Biomeditsinskaya khimiya, 2006, vol: 52(3), 309-316.
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