Erythrocytes and leucocytes in realization of com munication between lipid peroxidation and hemostasis

   


1. Tyumen State Academy
Type: Experimental/clinical study
UDK: 57. 052: 115: 616. 151. 5      PubMed Id: 17044595
Year: 2006 vol: 52  issue:4  pages: 370-377
Abstract: Investigation of 213 rats has shown that exposition containing normal plasma of erythrocytes, neutrophils or monocytes (physiological concentration) taken from the rats treated with prooxidant (lead acetate) or antioxidant (selmevite) causes corresponding increase or decrease of: a) both spontaneous aggregation and ATP-induced aggregation of thrombocytes, b) releasing P3 and P4 factors, c) their lipoperoxidation (LPO) intensity. The effect is released by LPO products released by erythrocytes and leucocytes into their environment.The efficacy of antioxidants (vitamins with antioxidant properties in particular) used for correcting hypercoagulative changes in oxidative stress in clinics is supposed to be due to their capacity for limiting lipidoxidation in erythrocytes, leukocytes and thrombocytes.
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Reference: Bichevsky A.Sh., Galjan S.L., Ralchenko I.V., Alborov R.G., Umutbaeva M.K., Rudzevich A., Vinokurova E.A., Erythrocytes and leucocytes in realization of com munication between lipid peroxidation and hemostasis, Biomeditsinskaya khimiya, 2006, vol: 52(4), 370-377.
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