Abstract: A study of peculiarities of aldehyde reductase (AR) activity changes in the skeletal muscle from 1.5-, 2-, 6-, 12-, 24-months old rats during immobilization stress has been carried out. It has been shown that 6- and 24-month old rats demonstrate the highest sensitivity to influence of prooxidant factors of immobilization stress. This included accumulation of conjugated dienes and Shiff bases in the muscle cells 30 minutes after the immobilization of animals from investigated age groups. These changes have been accompanied by activation of AR in 6-months old rats, however, the 24-months old rats have not shown changes in the enzyme activity. It is suggested that that age-dependent activity changes in AR-activity are one of the causes underlying different sensitivity of muscle cells to the conditions of oxidative stress which is formed during immobilization at different ontogenesis stages.
Reference: Fomina E.V., Davydov V.V., Age-dependent peculiarities of aldehyde reductase activity changes in the skeletal muscle of rats during immobilization stress, Biomeditsinskaya khimiya, 2006, vol:
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