Changes in kinetic properties of superoxide dismutase and glutathione peroxidase in the liver from rats and erythrocytes at deficiency of protein and additional dietary administration Cu, Zn, Mn and Se

   


1. Institute of Nutrition RAMS
Type: Experimental/clinical study
UDK: 616.155.1-008      PubMed Id: 17044597
Year: 2006 vol: 52  issue:4  pages: 384-393
Abstract: The kinetic parameters of liver and erythrocyte superoxide dismutase (SOD) and glutatione peroxidase (GP) have been investigated in rats kept under conditions of low protein diet (8%) and during addition of organic compounds containing Cu, Zn, Mn, Se. There were differences in kinetic parameters of hepatic and erythrocyte enzymes. After 2 and 4 weeks of maintenance of rats at a semi-synthetic diet there was an increase of Km value of liver and erythrocyte GP for tert-butyl hydroperoxide. After two weeks there was a decrease in Km of SOD for NADH-O2- generating system. The low protein diet and consumption of Cu, Zn, Mn, Se caused a decrease of Кm value of liver and erythrocytes GP and development of oxidative stress in liver as a result dietary administration Cu and Mn.
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Reference: Vasiljev A.V., Ivakhnenko V.I., Maltsev G.Yu., Changes in kinetic properties of superoxide dismutase and glutathione peroxidase in the liver from rats and erythrocytes at deficiency of protein and additional dietary administration Cu, Zn, Mn and Se, Biomeditsinskaya khimiya, 2006, vol: 52(4), 384-393.
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