The lipoprotein metabolism in arterial hypertension, type II diabetes mellitus, and metabolic syndrome

   


1. Institute of Neurology, Psychiatry and Narcology of the AMS of Ukraine
Type: Experimental/clinical study
UDK: 577.125:616.379-008.64:577.15.173      PubMed Id: 17044598
Year: 2006 vol: 52  issue:4  pages: 394-402
Abstract: The apoA- and apoB-containing lipoprotein (LP) fractions, activity of free and linked forms of lipoprotein lipases (LPL) of liver and extrahepatic tissues, and also activity of lecithin:cholesterol acyltransferase (LCAT) were examined in the blood serum of patients with arterial hypertension, type II diabetes mellitus (DM-II), and metabolic syndrome (MS). Patients with DM-II had the most pronounced changes of all investigated LP fractions compared with healthy persons and patients of other groups examined. Decrease of LCAT activity corresponded to declining level of apoA-containing LP in DM-II and MS. Based on these data obtained we suppose, that one of peculiarities of LP metabolic disorders in the patients is a releasing of a part of lipolitic enzymes, located on the capillary endothelium, into blood flow. Heparin may have an important role in LPL redistribution, as its concentration in blood cells was declined in all the patients.
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Reference: Bozhko G.Kh., Sokolyk V.V., Chursina V.S., Pertseva T.G., The lipoprotein metabolism in arterial hypertension, type II diabetes mellitus, and metabolic syndrome, Biomeditsinskaya khimiya, 2006, vol: 52(4), 394-402.
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