А short test for potential carcinogenicity of water soluble synthetic polymers


1. N.N. Petrov Oncology Research Institute of the Ministry of Health of the Russian Federation
2. Institute of Macromolecular Compounds, Russian Academy of Sciences
Type: Experimental/clinical study
UDK: 541.64:541.69      PubMed Id: 17180924
Year: 2006 vol: 52  issue:5  pages: 495-506
Abstract: The effect of synthetic water-soluble polymer with different structure on the appearance in SZNA mice of carcinogen-protein adducts (CPA) containing endogenous carcinogen, 3 - oxyanthranilic acid (3 - OAA), was investigated. CPA containing 3-OAA (3- OAA-CPA) were detected during the administratiоn of 24 of 30 investigated polymers. The induction of 3-OAA-CPA and the character of their distribution in the organism (in all investigated tissues: serum, extracts of liver, spleen, lungs and kidneys tissues or in single tissues) depended on the chemical structure of polymers. It is concluded, that synthetic polymers represent potential cancerogenic danger, because their administratiоn causes formation of 3-OAA-CPA in the organism of animals.
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Reference: Belokhvostova A.T., Potapenkova L.S., Panarin E.F., Solovskij M.V., Ivanova N.P., Nazarova O.V., Gaurilova I.I., Jershov A. Ju., А short test for potential carcinogenicity of water soluble synthetic polymers, Biomeditsinskaya khimiya, 2006, vol: 52(5), 495-506.