Abstract: The effects of the activator of ATP-sensitive potassium channels (KATP) pinacidil (0.06 mg/kg) and the blocker of these channels glibenclamide (1 mg/kg) were investigated using liver and heart mitоchondria isolated from rats exhibiting high (HR) or low-resistance (LR) to hypoxia. The animals were subjected to emotional stress. Stress caused activation of mitochondrial succinate oxidation, the decrease of efficiency of alpha-ketoglutarate oxidation and intensification of lipid peroxidation (LPO). These changes were more pronounced in the LR-animals. Administration of pinacidil protected mitochondria under conditions of stress, of whereas glibenclamide abolished these changes.
Reference: Kurhalyuk N.N., Tkachenko G.M., Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of atp-sensitive potassium channels, Biomeditsinskaya khimiya, 2006, vol:
1. McCully J.D., Levitsky S. (2003) Ann. Thorac. Surg., 75, 667-673.