The activity of 11β-hydroxysteroid dehydrogenase of rat kidney and liver at inherited stress-induced arterial hypertension

   


1. Institute of Laser Physics, Siberian Branch of Russian Academy of Sciences
Type: Experimental/clinical study
UDK: 616.154:577.175.53      PubMed Id: 17288248
Year: 2006 vol: 52  issue:6  pages: 568-575
Abstract: 11β-hydroxysteroid dehydrogenase (11β-HSD) is the key enzyme of glucocorticoid metabolism, which catalyzes interconversion of corticosterone and 11-dehydrocorticosterone in rat. The activity of 11β-HSD in kidneys of rats with inherited stress-induced arterial hypertension (ISIAH) was significantly (p<0.05) higher than that in WAG rats. The opposite was observed in the activity of liver 11β-HSD. Under stress condition no changes in the kidney 11β-HSD activity of both strains were observed, but the liver 11β-HSD activity in ISIAH rats was significantly (p<0.05) higher as compared to basal level and stressed WAG rats. It is possible that the features of the 11β-HSD activity in ISIAH rats may reflect the hypertensive status of ISIAH rats.
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Reference: Cherkasova O.P., The activity of 11β-hydroxysteroid dehydrogenase of rat kidney and liver at inherited stress-induced arterial hypertension, Biomeditsinskaya khimiya, 2006, vol: 52(6), 568-575.
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