Antioxidant enzymes in skin experimental burn trauma


1. Department of Molecular Biology, Russian State Medical University
2. Department of Physiology, Russian State Medical University
Type: Experimental/clinical study
UDK: 577.15.158:616.5.001.17      PubMed Id: 17288249
Year: 2006 vol: 52  issue:6  pages: 576-586
Abstract: The effect of experimental burn trauma (20%) on myeloperoxidase (MPO) and antioxidant enzymes (catalase, glutathione peroxidase (GPO), glutathione-S-transferase (GST)) was studied in unburned skin, epidermis (20 mm from the burned area) and the wound tissue of rats. The most common features were the increase of MPO on the 1st day and a delayed increase of GPO and GST after the 4th day. The additional operations (necrectomy) and lipopolysaccharide administration induced marked inflammatory reaction in skin and epidermis (evaluated by the increase in MPO and GPO/GST activities).
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Reference: Mikhal'chik E.V., Titkova S.M., Anurov M.V., Pen'kov L.Yu., Korkina L.G., Antioxidant enzymes in skin experimental burn trauma, Biomeditsinskaya khimiya, 2006, vol: 52(6), 576-586.