Abstract: The effect of experimental burn trauma (20%) on myeloperoxidase (MPO) and antioxidant enzymes (catalase, glutathione peroxidase (GPO), glutathione-S-transferase (GST)) was studied in unburned skin, epidermis (20 mm from the burned area) and the wound tissue of rats. The most common features were the increase of MPO on the 1st day and a delayed increase of GPO and GST after the 4th day. The additional operations (necrectomy) and lipopolysaccharide administration induced marked inflammatory reaction in skin and epidermis (evaluated by the increase in MPO and GPO/GST activities).
2. Baskaran H., Yarmush M.L., Berthiamue F. (2000) J.Surg Res., 93, 88-96. . Scholar google search
3. Porto da Rocha R., Lucio D.P., de Lima Souza T., Pereira S.T., Fernandes G.J.M. (2002) Aesth. Plast.Surg., 26, 197-202. . Scholar google search
4. Oliveira G.V., Shimoda K., Enkhbaatar P., Jodoin J., Burke A.S., Chinkes D.L., Hawkins H.K., Herdndon D.N., Traber L., Traber D., Murakami K. (2004) Shock, 22, 278-282. . Scholar google search
5. Goldstein R.K., Augustin A., Milz J ., Burg G., Lutz J. (1992) in Oxygen Transport to Tissue XIII (Goldstick et al ed.), Plenum Press, N.Y., pp.253-258. . Scholar google search
6. Thiele J.J., Schroeter C., Hsieh S.N., Podda M., Packer L. (2001) in Oxidants and Antioxidants in Cutaneous Biology. Curr. Probl. Dermatol. (Thiele J., Elsner P. eds), Basel, Karger, vol.29, pp 26-42. . Scholar google search
7. Steiling H., Munz B., Werner S., Brauchle M. (1999) Exp.Cell Res., 247, 484-494. . Scholar google search
8. Hanselmann C., Mauch C., Werner S. (2001) Biochem. J., 353, 459-466. . Scholar google search
9. Kono Y., Fridovich I. (1982) J. Biol. Chem., 257, 5751-5754. . Scholar google search
10. Naziroglu M., Kokcam I., Yilmaz S. (2003) Skin Pharmacol. Appl. Skin Physiol., 16, 36-45. . Scholar google search
11. Garner W.L., Rodriguez J.L., Miller C.G., Till G.O., Rees R.S., Smith D.J., Remick D.G. (1994) Surgery, 116, 42-48. . Scholar google search
12. Troshev K., Kozarev I., Markov D. (1990) Acta Chir. Plast., 32, 152-163. . Scholar google search
13. Lowry O.H., Rosebrough N.J., Farr A.L, Randall R.J. (1951) J. Biol. Chem., 193, 265-275. . Scholar google search
14. Andrews P.C., Krinsky N.I. (1985) in CRC Handbook of Methods for Oxygen Radical Research (Greenwaid R., ed.), Boca Raton, Florida, pp. 297-302. . Scholar google search
