Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids

   


1. Russian Cardiology Scientific Research Center
2. Faculty of Basic Medicine, Lomonosov Moscow State University
Type: Experimental/clinical study
UDK: 547.915.5-547.458.2-577.15      PubMed Id: 17436686
Year: 2007 vol: 53  issue:1  pages: 65-71
Abstract: Previous studies demonstrated that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits inflammatory effects of the bacterial lipopolisacharide (LPS, endotoxin). In this work we have characterized the anti-endotoxin activity of other classes of oxidized phospholipids with different polar head groups and fatty acid residues. LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. The anti-endotoxin effect insignificantly depended on the type of polyunsaturated fatty acids. Unoxidized phospholipids did not suppress effects of LPS. Thus, the anti-endotoxin activity of oxidized phospholipids crucially depends on the presence of oxidatively modified fatty acid residue.
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Reference: Korotaeva A.A., Samokhodskaya L.M., Bochkov V.N., Inhibition of lypopolysaccharide-induced inflammation by oxidized phospholipids, Biomeditsinskaya khimiya, 2007, vol: 53(1), 65-71.
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