Glutathione system in erythrocytes and blood plasma in viral hepatites

   


1. Irkutsk State Medical University
Type: Experimental/clinical study
UDK: 577.17:616.36-002.14:612.111      PubMed Id: 17436689
Year: 2007 vol: 53  issue:1  pages: 91-98
Abstract: In all 5 acute (AVHs) and chronic viral hepatites (CVHs) there was the increase of erythrocyte activities of glutathione peroxidase (GPx) and glutathione reductase (GR), and the decrerase in GSH concentration. In blood plasma there was accumulation of GPx, glutathione S-transferase (GST) and γ-glutamyl transferase (γGT). GSH and GR increased in plasma only in AVHs. In CVH C erythrocyte GST increased. Evidently changes in the erythrocyte glutathione system are reactions to oxidative stress and in blood plasma they are consequences of inflammation and hepatocyte cytolysis. Changes were more pronounced in middle-heavy course than in the heavy one. These changes have pathogenic importance and can be used in addition to complex diagnostics. They are significantly differed from changes in chronic gall-bladder diseases. Necessity of separate investigation of glutathione system in erythrocytes and blood plasma but not in whole blood is argued.
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Reference: Kulinsky V.I., Leonova Z.A., Kolesnichenko L.S., Malov I.V., Danilov Yu.A., Glutathione system in erythrocytes and blood plasma in viral hepatites, Biomeditsinskaya khimiya, 2007, vol: 53(1), 91-98.
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