Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action"

   


1. Bashkortostan State University
2. Ufa State Petroleum Technological University
3. Institute of Organic Chemistry, Ufa Science Centre of RAS
Type: Experimental/clinical study
UDK: 004.382.7:615      PubMed Id: 17722576
Year: 2007 vol: 53  issue:3  pages: 266-275
Abstract: Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.
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Reference: Khayrullina V.R., Mukhametov A.D., Tjurina L.A., Garifullina G.G., Gerchikov A.J., Zarudiy F.S., Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure - the effectiveness of anti-inflammatory action", Biomeditsinskaya khimiya, 2007, vol: 53(3), 266-275.
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