Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer

   


1. Departments of Biochemistry and Molecular Biology, Siberian State Medical University
Type: Experimental/clinical study
UDK: 616.342-002.44:616.153.96      PubMed Id: 17722585
Year: 2007 vol: 53  issue:3  pages: 338-344
Abstract: The aim of this study was to determine correlation between proteolysis parameters and phenotypes of α1-proteinase inhibitor in blood plasma in children with duodenal ulcer. Activation of pepsin- and trypsin like proteinases was accompanied by the decrease in activity of α2-macroglobulin and the increase in activity of acid stable inhibitors. The phenotypes М1М3, М1М1, М2М2 of α1-proteinase inhibitor were determined. Activation of proteolysis was more pronounced in individuals with subtype М2М2. Activity of α1-proteinase inhibitor decreased by 2-fold in М2М2, insignifically differed from the control group in М1М1, and increased by 1,9-fold in М1М3 subtype. Low activity of α1-proteinase inhibitor was accompanied by high activity of acid stable inhibitors; this may be regarded as the protective reaction of the body. Determination of α1-proteinase inhibitor phenotypes may be a basis for employment of polyvalent proteinase inhibitors for therapy of ulcer.
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Reference: Akbasheva O.E., Parameters of plasma blood proteolysis and phenotypes ofα1-proteinase inhibitor in children with duodenal ulcer, Biomeditsinskaya khimiya, 2007, vol: 53(3), 338-344.
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