Free radical processes in aging, neurodegenerative diseases and other pathological states

   


1. Psychoneurological Bekhterev Institute
2. D.O. Ott Institute of Obstetrics and Gynecology RAMS
Type: Review
UDK: 577.344      PubMed Id: 18035718
Year: 2007 vol: 53  issue:4  pages: 351-371
Abstract: Literature data on the role of oxidative stress in the ageing of an organism have been summarized. The connection of some parameters of free radical processes (intensity of generation of reactive oxygen species in mitochondria, oxidative modification to the mitochondrial DNA, the activity of desaturases participating in biosynthesis of polyunsaturated С20 and С22 fatty acids) with life expectancy has been demonstrated. Oxidative stress is one of pathogenetical events in many diseases, including various neurodegenerative disorders. The special attention is paid to oxidatively modified proteins as one of early and reliable indicators of tissue injury in freeradical pathology. Oxidative protein destruction plays an important role in etiology of such neurodegenerative diseases, as Alzheimer`s and Parkinson`s diseases. Oxidative stress and the aggregation of proteins connected with it are considered to be a pathogenetical part in the development of familial amyotrophic lateral sclerosis. Oxidatively modified proteins are also associated with the development of cataract. The increase of the oxidatized protein ratio with the age and in various pathologies is assessed as an early and specific parameter of oxidative stress.
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Reference: Dubinina E.E., Pustygina A.A., Free radical processes in aging, neurodegenerative diseases and other pathological states, Biomeditsinskaya khimiya, 2007, vol: 53(4), 351-371.
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