Biochemical and photometric studies of modification of collagen structure under uv radiation

   


1. Scientific Research and Eduction Centre of Biomedical Technology
Type: Experimental/clinical study
UDK: 612.67 575.7+616.092      PubMed Id: 18035725
Year: 2007 vol: 53  issue:4  pages: 442-453
Abstract: The influence of UV irradiation (270-380 nm) on the biochemical, fluorescence and colorimetric properties of collagen was studied. The long-term UV irradiation (120 h) was accompanied by the increase of structural stability of collagen to specific and nonspecific proteolytic enzymes, by formation of new additional fluorophore-containing molecules, by the increase in quantity of carbonyl groups in the collagen and by strong changing of the distribution pattern of alkaline hydrolysis products during gel-chromatography. The coordinates of colour of the collagen films are also changed. These changes of collagen suggest that UV irradiation induces photomodification and photooxidation processes in collagen.
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Reference: Rebrova G.A., Vasilevsky V.K., Rebrov L.B., Osipova L.A., Bykov V.A., Biochemical and photometric studies of modification of collagen structure under uv radiation, Biomeditsinskaya khimiya, 2007, vol: 53(4), 442-453.
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