1. Department of Bioinorganic and Bioorganic Chemistry, Irkutsk State Medical University 2. Department of Biochemistry, Irkutsk State Medical University 3. Department of Neurology and Neurosurgery, Irkutsk State Institute of Physician Training 4. Department of Clinical Pharmacology, Irkutsk State Institute of Physician Training
Abstract: In dyscirculatory encephalopathy and moderate ischemic stroke there are single changes of components of glutathione metabolism. In moderate and severe ischemic stroke frequent and considerable changes have been revealed. Changes in hemorrhagic stroke are also expressed. An increase of activities of glutathione peroxidase and glutathione transferase is the most typical, rarely the increase of glutathione reductase and GSH is observed. The increase of enzymes activity was absent at the delayed oneset of treatment (more than 3 days) and in severe cases patients who died later. Glutathione system is important in the tolerance to cerebral ischemia.
Reference: Kolesnichenko L.S., Kulinsky V.I., Shprakh V.V., Bardymov V.V., Verlan N.V., Gubina L.P., Pensionerova G.A., Sergeeva M.P., Stanevich L.M., Philippova G.T., Glutathione system in erythrocyte and blood plasma in strokes and dyscirculatory encephalopathy, Biomeditsinskaya khimiya, 2007, vol: