Phospholipid composition of erythrocyte membranes under conditions of postmyocardial infarction cardiosclerosis

   


1. Research Institute for Сardiology, Tomsk Research Centre, of Russian Academy of Medical Sciences Siberian Branch
Type: Experimental/clinical study
PubMed Id: 18078068
Year: 2007 vol: 53  issue:5  pages: 541-546
Abstract: Changes in phospholipid composition of the erythrocyte membranes have been studied in experimental postmyocardial infarction cardiosclerosis. Erythrocyte membranes from animals with cardiosclerosis formed aftr experimantal occlusions of coronary arteries were characterized by significant decrease of a minor phospholipid, phosphatydylinositol (by more than 40%) and the increase of the major phospholipid, phosphatydylethanolamine. There was high content of lipid peroxidation products, malondialdehyde and conjugated dienes and the decrease in the activity of antioxidant enzymes, catalase and superoxide dismutase in blood serum of these animals.We have concluded the formation of postmyocardial infarction cardiosclerosis is accompanied by the increase of free radical reactions. This causes changes in phospholipid composition of cell membranes and the decrease of compensatory capacities of the enzymatic antioxidant system. These changes form a metabolic backgroung, which can influence cardiac remodelling properties.
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Reference: Afanasyev S.A., Rebrova T.Y., Kondratieva D.S., Phospholipid composition of erythrocyte membranes under conditions of postmyocardial infarction cardiosclerosis, Biomeditsinskaya khimiya, 2007, vol: 53(5), 541-546.
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