Abstract: In the human myocardium tissue, proteomic technologies revealed the products of 2 genes (α-actin and albumin), existing as fragments; their appearance and increased contents correlated with age. The age-related variants differ from the mature forms by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-dependent proteins were found in 50% of cases (in the age group 31-40 years), while in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the cardiac musсle and also of the adaptation - dysadaptations mechanisms in the CIHD.
Reference: Kovalyova M.A., Kovalyov L.I., Serebryakova M.V., Moshkovskii S.A., Shishkin S.S., Age-related changes of albumin and actin of human myocardium, Biomeditsinskaya khimiya, 2007, vol: