Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation

   


1. Institute of Physiology Siberian Branch of Russian Academy of Medical Sciences
2. Novosibirsk Regional Cardiology Unit
Type: Experimental/clinical study
UDK: 616-006.446.2      PubMed Id: 18522223
Year: 2008 vol: 54  issue:2  pages: 210-217
Abstract: Cystatin C belongs to the group of wide spread extracellular cysteine protease inhibitors. Using ELISA kits it was shown that the highest cystatin C concentration was in human cerebrospinal fluid and low cystatin C concentration was in human urine. In healthy young persons serum cystatin C concentration was lower than in elder patients (50-65 year old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. According to these data one can conclude that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several kinds of hemoblastoses.
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Reference: Korolenko T.A., Filatova T.G., Cherkanova M.S., Khalikova T.A., Bravve I.Yu., Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation, Biomeditsinskaya khimiya, 2008, vol: 54(2), 210-217.
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