Determination of "amino acids conflicts" and amino acids substitutions in primary structures of 41 human proteins by use the proteomic technologies

   


1. Bakh Institute of Biochemistry, Russian Academy of Sciences
2. Orekhovich Institute of Biomedical Chemistry
3. Institute of Physico-Chemical Medicine
Type: Experimental/clinical study
UDK: 577.122      PubMed Id: 18988458
Year: 2008 vol: 54  issue:4  pages: 420-434
Abstract: Proteomic studies of some human tissues and organs (skeletal muscles, myometrium, motor zone of the brain, prostate), and also cultivated myoblasts revealed 41 of 300 identified proteins, in which the present of certain variants of amino acids ("conflicts") was recognized at several positions. Among the 93 registered amino acids "conflicts", seven cases represented the results of the protein polymorphisms caused by corresponding substitution of individual amino acid. Moreover, among prostate proteins the proteomic analysis revealed two isoforms of prostate-specific antigen, formed due to alternative splicing. Thus, our results have shown, that proteomic technologies allow to specify effectively the features of primary structures and to characterize various kinds of polymorphism in many human proteins.
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Reference: Kovalyova M.A., Kovalyov L.I., Eryomina L.S., Makarov A.A., Burakova M.V., Toropygin I.Y., Serebryakova M.V., Shishkin S.S., Archakov A.I., Determination of "amino acids conflicts" and amino acids substitutions in primary structures of 41 human proteins by use the proteomic technologies, Biomeditsinskaya khimiya, 2008, vol: 54(4), 420-434.
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