Native and chiral modified NMDA-receptor NR1-binding core ligands modeling


1. Lipetsk Branch of Orel Regional Academy of State Service
2. School of Physics, Lomonosov Moscow State University
Type: Short communication
UDK: 577.3:577.355      PubMed Id: 18988464
Year: 2008 vol: 54  issue:4  pages: 477-481
Abstract: Native and chiral modified (with non-enzymatic Asn racemization) NR1-binding core of NMDA-receptor was modelled by means of molecular dynamic ligand modelling. It was concluded that Gly, D-Ser, D-Asn and D-Thr are ligands of NR1-binding core native NMDA-receptor, whereas the chiral modified NR1-binding core is characterized by the aliphatic non-polar amino acids D-Ala, D-Leu, D-Ile and D-Pro as ligands. The latter amino acids can be considered as effective ligands of NMDA-receptor NR1-binding core in age-related pathology.
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Reference: Korotina A.S., Dmitriev A.V., Tverdislov V.A., Native and chiral modified NMDA-receptor NR1-binding core ligands modeling, Biomeditsinskaya khimiya, 2008, vol: 54(4), 477-481.
This paper is also available as the English translation:10.1134/S1990750808040033