Abstract: The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
7. Lorenzi P.L., Reinhold W.C., Rudelius M., Gunsior M., Shankavaran U., Bussey K.J., Scherf U., Eichler G.S., Martin S.E., Chin K., Gray J.W., Kohn E.C., Horak I.D., Von Hoff D.D., Raffeld M., Goldsmith P.K., Caplen N. J., Weinstein J.N. (2006) Mol. Cancer Ther., 5, 2613-2623.
8. Taylor C.W., Dorr R.T., Fanta P., Herch E.M., Salmon S.E. (2001) Cancer Chemother. Pharmacol., 47, 83-88.