Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis


1. Orekhovich Institute of Biomedical Chemistry Russian Academy of Medical Sciences
2. Research Institute of Genetics
3. Research Institute of Human Morphology Russian Academy of Medical Sciences
Type: Short communication
UDK: 612-006.577.15      PubMed Id: 19205431
Year: 2008 vol: 54  issue:6  pages: 712-719
Abstract: The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
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Reference: Abakumova O.Yu., Podobed O.V., Borisova A.A., Sidoruk K.V., Alexandrova S.S., Omelyanuk N.M., Pokrovskaya M.V., Kondakova L.I., Sokolov N.N., Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis, Biomeditsinskaya khimiya, 2008, vol: 54(6), 712-719.
This paper is also available as the English translation:10.1134/S1990750809020115