Particuliarities of glycolysis in liver and skeletal muscle after acute alcohol intoxication in rats

   


1. Grodno State Medical University
2. Institute of Farmacology and Biochemistry
Type: Experimental/clinical study
UDK: 612.396.22: 591.175/436: 616.89-008      PubMed Id: 19351040
Year: 2009 vol: 55  issue:1  pages: 106-113
Abstract: Functional activity of glycolysis was studied in liver and skeletal muscles of rats subjected to acute alcohol intoxication. Alcohol administration in the dose of 1 g/kg led to inhibition of glycolytic enzymes activities and decreased levels of some glycolytic substrates in liver. Activity of LDH increased in skeletal muscle under these experimental conditions. Moderate dose of ethanol (2.5 g/kg) activated glucogenolysis and increased glucose level in liver. In this group inhibition of PFK activity and decrease of glucose-6-phosphate level in muscle was also observed. Alcohol administration in the dose of 5 g/kg caused inhibition of rate-limiting enzymes of glycolysis in liver and muscle.
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Reference: Lelevich S.V., Borodinsky A.N., Particuliarities of glycolysis in liver and skeletal muscle after acute alcohol intoxication in rats, Biomeditsinskaya khimiya, 2009, vol: 55(1), 106-113.
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