Immunochemical and molecular-genetic markers in gastric cancer diagnostics

   


1. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
2. Novosibirsk Oncological Dispensary
3. Cancer Research Institute, Siberian Division of the Russian Academy of Medical Sciences
Type: Review
UDK: 611.33-616.006.66-57.089      PubMed Id: 19351030
Year: 2009 vol: 55  issue:1  pages: 15-31
Abstract: Studies of molecular mechanisms of neoplastic transfromation are being under the thorough investigation, reveal the new genes involved into the tumor development. These genes and their products are potential tumor markers and levels of their expression can be detected using modern assays characterized by high specificity and sensitivity. The review highlights the current status of the molecular diagnostics of gastric cancer, including protein and nucleic acids biomarkers. The genetic and epigenetic changes, which are detected in the malignant and nonmalignant tumor tissue DNA and in the blood plasma DNA from tumor bearing patients, are summarized.
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Reference: Elistratova E.V., Laktionov P.P., Shelestuk P.I., Tuzikov S.A., Vlassov V.V., Rykova E.Y., Immunochemical and molecular-genetic markers in gastric cancer diagnostics, Biomeditsinskaya khimiya, 2009, vol: 55(1), 15-31.
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