The stydy of the human complement cascade of proteolysis as a target of laser irradiation

   


1. Pavlov St-Peterburg State Medical University
Type: Experimental/clinical study
UDK: 577.112      PubMed Id: 19351035
Year: 2009 vol: 55  issue:1  pages: 68-72
Abstract: Samples of human blood plasma were irradiated with the laser beam (λ=633 nm, P=13 mW, t=20 min) in vitro. In experimental and control (incubated in the dark) samples the complement hemolytic activity was measured. Laser irradiation had minor influence on the duration of lag-period and the rate of complement-dependent hemolysis via classical and alternative pathways; it also did not alter the functional activity of factor B, components C2 and C3. Nevertheless laser irradiation effect was seen in essential reduction of a bystander lysis coefficient. This new fact can elucidate some aspects of the clinical effectiveness of the blood laser irradiation.
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Reference: Galebskaya L.V., Andreeva L.A., Solovtsova I.L., Petrishchev N.N., Solov'eva M.A., The stydy of the human complement cascade of proteolysis as a target of laser irradiation, Biomeditsinskaya khimiya, 2009, vol: 55(1), 68-72.
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