Catalytic properties of glutathione reductase from rats liver at norm and toxic hepatites

   


1. Voronezh State University, Biology and Soil Science Faculty
Type: Experimental/clinical study
UDK: 577.152.1:616      PubMed Id: 19507340
Year: 2009 vol: 55  issue:2  pages: 169-176
Abstract: Homogeneous preparations of liver glutathione reductase (GR, EC 1.6.4.2.), obtained from control rats and animals with toxic hepatitis, catalytic properties of this enzyme have been investigated. A number of the enzyme properties did not change under conditions of hepatitis These included electrophoretic mobility (Rf=0,23±0,01), molecular mass (104±5,20 kDa), pH-optimum (7,4±0,37). There was similarity in рК values of functional groups. At the same time, decrease in affinity of enzyme to a substrate and coenzyme and occurrence substrate-linked inhibition was observed under conditions of this pathology. There were some differencies in regulation of GR activity by metabolites of tricarboxylic acid cycle.
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Reference: Agarkov A.A., Popova T.N., Semenikhina A.V., Catalytic properties of glutathione reductase from rats liver at norm and toxic hepatites, Biomeditsinskaya khimiya, 2009, vol: 55(2), 169-176.
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