1. A.V. Topchiev Institute of petrochemical synthesis, Russian Academy of Sciences 2. A.N. Bakh Institute of Biochemistry, Russian Academy of Sciences 3. Scientific Center of Endocrinology, Russian Academy of Medical Sciences
Abstract: Oral administration of diluted solutions of insulin results in the absorption of the hormone into bloodstream. After oral administration of diluted insulin solutions to healthy volunteers and animals with experimental diabetes insulin does not undergo hydrolytic degradation under the action of proteolytic enzymes and its absorption is sufficient to produce the hypoglycemic effect. This approach gives a chance of creating of novel strategy for diabetes treatment.
Reference: Valuev L.I., Sytov G.A., Valuev I.L., Vanchugova L.V., Valueva T.A., Plate N.A., Starosel'tseva L.K., Ul'yanova M.V., Oral insulin preparations for the regulation of the glucose level in the blood, Biomeditsinskaya khimiya, 2009, vol:
1. Марри Р., Греннер Д., Мейес П. и др. (1993) Биохимия человека, М.: Мир, с. 284-297. Scholar google search
2. Sekigami T., Shimoda S., Nishida K. et al. (2004) J. Artif. Organs, 7, №2, 91-100. Scholar google search
3. Saffran M., Pansky B., Collin Budd G. et al. (1997) J. Controlled release, 46, 89-98. Scholar google search