Biomarkers in the modern medical and biologic practice


1. Mental Health Research Center Russian Academy of Medical Science
Type: Experimental/clinical study
UDK: 547.61.57      PubMed Id: 20000121
Year: 2009 vol: 55  issue:4  pages: 425-440
Abstract: The lecture deals with biomarkers, a newly introduced direction in biomedical research. The following terms, definitions, and characteristics were proposed to describe biomarkers: diagnostic tools, clinical endpoints and surrogate endpoints. Examples of predictors for cardiovascular diseases, acute-phase of inflammation and malignant tumors are represented. The special attention is given to the characteristic of the widespread biomarkers: homocysteine, transthyretin and C-reactive protein. Modern methods of identification, qualitative and quantitative determination of biomarkers are considered: mass spectrometric methods, immunoassay. The relationships between the latest achievements in the field of genomics, proteomics, bioinformatics and biomarker's investigations are established. The perspectives of biomarkers are discussed.
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Reference: Miroshnichenko I.I., Ptitsina S.N., Biomarkers in the modern medical and biologic practice, Biomeditsinskaya khimiya, 2009, vol: 55(4), 425-440.